Sodium Oxybate

Category: pharmacological

Aliases: Xyrem, GHB sodium

Pharmacological Mechanism

Sodium salt of γ-hydroxybutyrate (GHB) — GABA-B agonist + GHB-receptor agonist. Approved for narcolepsy with cataplexy. Schedule III when prescribed; the parent compound GHB is Schedule I as a date-rape drug.

Half-Life (t½)

PO: 0.5h

Dosing Guidelines

• PO: Typical 6000mg (Range: 4500 - 9000 mg)

Target Organ Systems

• nervous