Sitoindoside IX

Category: terpenoid

Aliases: Sitoindoside-IX

Pharmacological Mechanism

Glycowithanolide of the sitoindoside class (IX + X are most-studied). Preclinical immunomodulatory + adaptogenic activity (anti-stress, anti-fatigue). Reported as a marker compound in multiple ashwagandha extract analyses. Like other glycowithanolides, requires gut/hepatic hydrolysis for systemic free-aglycone exposure.

Dosing Guidelines

• PO: Typical 5 mg (Range: 1–30 mg)

Target Organ Systems

• nervous
• immune-hematologic

Notes

Glycowithanolide; clinical effect likely transduced through aglycone exposure. Sitoindosides IX + X are the most-studied of this class.

Pathways It Modulates

• Adaptogen HPA / cortisol stress modulation (inhibitor) — HPA cortisol (preclinical anti-stress)

Chemical Identifiers

• PubChem CID: 189586
• Formula: C34H48O11
• Molecular weight: 784.97 g/mol
• InChIKey: WKCJIGSUKSPCKI-WNXUODGFSA-N
• SMILES: CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O