Simethicone

Category: pharmacological

Aliases: Gas-X

Pharmacological Mechanism

OTC anti-foaming silicone polymer — disrupts gas-bubble surface tension in GI tract, allowing trapped gas to coalesce + pass. Inert; not absorbed. Colicky-infant + adult-bloating relief; modest benefit in clinical trials.

Half-Life (t½)

PO: 1h

Dosing Guidelines

• PO: Typical 80 mg (Range: 40–250 mg)

Target Organ Systems

• digestive

Pathways It Modulates

• GI motility + secretion (activator) — surface tension reducer (no receptor)

Chemical Identifiers

• PubChem CID: 6433516
• Formula: C6H18O4Si3
• Molecular weight: 238.46 g/mol
• InChIKey: AMTWCFIAVKBGOD-UHFFFAOYSA-N
• SMILES: CO[Si](C)(C)O[Si](C)(C)C.O=[Si]=O