Silychristin

Category: flavonoid

Pharmacological Mechanism

Flavonolignan in the silymarin complex; second-most abundant after silybin. Inhibits MCT8 (monocarboxylate transporter 8) → thyroid hormone uptake interference (Johannes 2016 — potentially relevant for AHDS patients). Otherwise similar hepatoprotective profile to silybin.

Dosing Guidelines

• PO: Typical 30 mg (Range: 10–100 mg)

Target Organ Systems

• digestive

Chemical Identifiers

• PubChem CID: 441764
• Formula: C25H22O10
• Molecular weight: 482.44 g/mol
• InChIKey: BMLIIPOXVWESJG-LMBCONBSSA-N
• SMILES: COC1=C(C=CC(=C1)[C@H]2[C@@H](C3=C(O2)C(=CC(=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)O)CO)O