Sevoflurane

Category: pharmacological

Aliases: Ultane

Pharmacological Mechanism

Inhaled fluorinated ether anesthetic — mechanism likely via GABA-A potentiation + glycine receptor + voltage-gated K+ channel modulation. Low blood-gas partition coefficient → rapid induction + emergence. Workhorse for pediatric mask induction; less pungent than isoflurane.

Half-Life (t½)

INH: 0.5h

Dosing Guidelines

• INH: Typical 2 mg (Range: 0.5–4 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Volatile anesthetic action (activator) — GABA-A + glycine + TASK-1/3 K+ channels

Chemical Identifiers

• PubChem CID: 5206
• Formula: C4H3F7O
• Molecular weight: 200.05 g/mol
• InChIKey: DFEYYRMXOJXZRJ-UHFFFAOYSA-N
• SMILES: C(OC(C(F)(F)F)C(F)(F)F)F