Sesamin

Category: polyphenol

Pharmacological Mechanism

Furofuran lignan from sesame seed oil. Inhibits Δ5-desaturase shifting fatty-acid balance toward DGLA; modest tocopherol-sparing effect. Trialed for blood pressure + lipid effects.

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 100 mg (Range: 50–200 mg)

Target Organ Systems

• cardiovascular

Pathways It Modulates

• Nrf2 / Keap1 antioxidant response (activator) — tocopherol-sparing + lipid

Chemical Identifiers

• PubChem CID: 72307
• Formula: C20H18O6
• Molecular weight: 354.35 g/mol
• InChIKey: PEYUIKBAABKQKQ-AFHBHXEDSA-N
• SMILES: C1[C@H]2[C@H](CO[C@@H]2C3=CC4=C(C=C3)OCO4)[C@H](O1)C5=CC6=C(C=C5)OCO6