Sertraline

Category: pharmacological

Aliases: Zoloft

Pharmacological Mechanism

SSRI with modest dopamine-transporter activity at high doses (σ-1 binding contributes). Weaker CYP interactions than fluoxetine. 26-h t½.

Half-Life (t½)

PO: 26h

Dosing Guidelines

• PO: Typical 100 mg (Range: 50–200 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• BDNF / TrkB neurotrophic signaling (activator) — BDNF/TrkB (chronic)
• Serotonin receptor pharmacology (inhibitor) — SERT
• SSRI/SNRI discontinuation syndrome (inhibitor) — SERT

Chemical Identifiers

• PubChem CID: 68617
• Formula: C17H17Cl2N
• Molecular weight: 306.23 g/mol
• InChIKey: VGKDLMBJGBXTGI-SJCJKPOMSA-N
• SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl

References

• PMID 10674711
• PMID 27082864
• PMID 27738376