Category: neurotransmitter
Aliases: 5-Hydroxytryptamine, 5-HT
Synthesised from [[5-htp]] (see [[serotonin_melatonin_axis]]) (AADC) in enterochromaffin cells (90% of body serotonin) and raphe nuclei (CNS pool). Acts at 14 receptor subtypes across the [[serotonin_receptor_pharmacology]] 5-HT1–7 families — all GPCRs except 5-HT3 (ligand-gated ion channel). Mood, sleep, nausea, GI motility, vasoconstriction.