Synthesised from 5 htp (see serotonin melatonin axis) (AADC) in enterochromaffin cells (90% of body serotonin) and raphe nuclei (CNS pool). Acts at 14 receptor subtypes across the serotonin receptor pharmacology 5-HT1–7 families — all GPCRs except 5-HT3 (ligand-gated ion channel). Mood, sleep, nausea, GI motility, vasoconstriction.
Target Organ Systems
nervous
cardiovascular
digestive
Interactions
5-HTP (synergistic): Immediate serotonin precursor — the practical supplement route.