Selank

Category: peptide

Aliases: TP-7 (tuftsin analog)

Pharmacological Mechanism

N-terminal addition of Thr-Lys-Pro-Arg (tuftsin) + C-terminal Pro-Gly-Pro stabilisation. Enhances BDNF expression, modulates enkephalin-degrading enzymes, and activates GABA-A without direct benzodiazepine-site binding. Anxiolytic without sedation or addiction potential (Russian trial data).

Half-Life (t½)

IN: 0.1h, SC: 0.2h

Dosing Guidelines

• IN: Typical 100 mcg (Range: 75–150 mcg)
• SC: Typical 100 mcg (Range: 75–150 mcg)

Target Organ Systems

• nervous

Interactions

• Semax (synergistic): Commonly paired in Russian protocols — Semax for cognitive, Selank for anxiolytic. Different ACTH/tuftsin backbones.

Notes

Heptapeptide (TKPRPGP) — tritium-tracer biodegradation studies (Zolotarev 2006) report rapid clearance (plasma t½ ~6-12 min). Effective duration in humans far exceeds plasma residence (downstream metabolites + epigenetic effects on BDNF / enkephalin pathways are PD, not PK). IN F is conservative; SC F treated as ≈1.0 for depot absorption.

Pathways It Modulates

• BDNF / TrkB neurotrophic signaling (activator) — BDNF (tuftsin analog; anxiolytic)
• Cognitive peptide axis (activator) — tuftsin + GABA + 5-HT (anxiolytic)

Chemical Identifiers

• PubChem CID: 11765600
• Formula: C33H57N11O9
• Molecular weight: 751.9 g/mol
• InChIKey: JTDTXGMXNXBGBZ-YVHUGQOKSA-N
• SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N3CCC[C@H]3C(=O)O)N)O

References

• PMID 16637290
• PMID 29787664