Saxagliptin

Category: pharmacological

Aliases: Onglyza

Pharmacological Mechanism

DPP-4 inhibitor — raises endogenous GLP-1 + GIP, promoting glucose-dependent insulin release. CYP3A4/5 substrate. Modest A1c reduction (~0.5%); slight heart failure signal vs sitagliptin.

Half-Life (t½)

PO: 3h

Dosing Guidelines

• PO: Typical 5 mg (Range: 2.5–5 mg)

Target Organ Systems

• cardiovascular
• endocrine
• digestive

Pathways It Modulates

• Insulin signaling + glucose homeostasis (inhibitor) — DPP-4

Chemical Identifiers

• PubChem CID: 11243969
• Formula: C18H25N3O2
• Molecular weight: 315.41 g/mol
• InChIKey: QGJUIPDUBHWZPV-SGTAVMJGSA-N
• SMILES: C1[C@@H]2C[C@@H]2N([C@@H]1C#N)C(=O)[C@H](C34CC5CC(C3)CC(C5)(C4)O)N

References

• PMID 22496391
• PMID 22475049