Category: pharmacological
Aliases: Component of Entresto
Neprilysin inhibitor prodrug — active metabolite LBQ657 inhibits NEP, raising natriuretic peptides (BNP, ANP) → vasodilation, natriuresis, anti-fibrotic. Always co-formulated with valsartan as Entresto for HFrEF; ACE inhibitor washout 36h required to avoid angioedema.
PO: 11h