Ropinirole

Category: pharmacological

Aliases: Requip

Pharmacological Mechanism

Non-ergot dopamine agonist at D2 and D3 receptors; used in Parkinson's disease and restless legs syndrome. Hepatic CYP1A2 metabolism (interacts with CYP1A2 inhibitors/inducers).

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 2 mg (Range: 0.25–8 mg)

Target Organ Systems

• nervous

Notes

PK from FDA prescribing information (DailyMed setid e32ef7a6-b4b6-4a22-a2ed-722255b486b4, IR film-coated tablet): absolute bioavailability 45–55% (F 0.50), apparent Vd 7.5 L/kg (~525 L at 70 kg), elimination t½ ~6 h, Tmax ~1–2 h, hepatic CYP1A2 metabolism. ka_hr 2.0 derived from Tmax ~1.5 h (ke from t½ 6 h).

Chemical Identifiers

• PubChem CID: 5095
• Formula: C16H24N2O
• Molecular weight: 260.37 g/mol
• InChIKey: UHSKFQJFRQCDBE-UHFFFAOYSA-N
• SMILES: CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1

References

• PMID 9057850