Rocuronium

Category: pharmacological

Aliases: Zemuron

Pharmacological Mechanism

Aminosteroid non-depolarizing neuromuscular blocker — competitive nicotinic ACh receptor antagonist at the motor endplate. Workhorse intubating muscle relaxant; rapid onset (~60 sec). Reversal with sugammadex (encapsulating agent) or neostigmine + glycopyrrolate.

Half-Life (t½)

IV: 1.5h

Dosing Guidelines

• IV: Typical 1 mg (Range: 0.6–1.2 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Neuromuscular junction blockade + reversal (inhibitor) — nAChR (non-depolarizing competitive antagonist)
• Nicotinic ACh receptor pharmacology (inhibitor) — NMJ non-depolarizing blocker (intermediate-acting)

Chemical Identifiers

• PubChem CID: 441290
• Formula: C32H53N2O4+
• Molecular weight: 529.78 g/mol
• InChIKey: YXRDKMPIGHSVRX-OOJCLDBCSA-N
• SMILES: CC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C