Rizatriptan

Category: pharmacological

Aliases: Maxalt

Pharmacological Mechanism

5-HT1B/1D agonist — second-generation triptan; faster oral onset and higher receptor potency than sumatriptan. Orally disintegrating tablet useful when migraine causes nausea. MAO-A substrate (dose adjust with propranolol).

Half-Life (t½)

PO: 2h

Dosing Guidelines

• PO: Typical 10 mg (Range: 5–10 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Serotonin receptor pharmacology (activator) — 5-HT1B/1D

Chemical Identifiers

• PubChem CID: 5078
• Formula: C15H19N5
• Molecular weight: 269.35 g/mol
• InChIKey: ULFRLSNUDGIQQP-UHFFFAOYSA-N
• SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3

References

• PMID 11680669