Risedronate

Category: pharmacological

Aliases: Actonel

Pharmacological Mechanism

Aminobisphosphonate — same osteoclast apoptosis mechanism as alendronate. Less GI irritation; weekly + monthly dosing options. Postmenopausal osteoporosis + glucocorticoid-induced osteoporosis prevention.

Half-Life (t½)

PO: 480h

Dosing Guidelines

• PO: Typical 35 mg (Range: 5–150 mg)

Target Organ Systems

• digestive
• musculoskeletal

Pathways It Modulates

• Bone remodeling (inhibitor) — osteoclast farnesyl-PP synthase

Chemical Identifiers

• PubChem CID: 5245
• Formula: C7H11NO7P2
• Molecular weight: 283.11 g/mol
• InChIKey: IIDJRNMFWXDHID-UHFFFAOYSA-N
• SMILES: C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)O

References

• PMID 11405286