Riociguat

Category: pharmacological

Aliases: Adempas

Pharmacological Mechanism

Soluble guanylate cyclase (sGC) stimulator — sensitizes sGC to NO + activates the NO-independent site. Raises cGMP → pulmonary vasodilation. Approved for PAH + chronic thromboembolic pulmonary hypertension (CTEPH). Contraindicated with PDE5 inhibitors + nitrates (additive hypotension).

Half-Life (t½)

PO: 12h

Dosing Guidelines

• PO: Typical 1mg (Range: 1 - 2.5 mg)

Target Organ Systems

• cardiovascular
• respiratory