Rimegepant

Category: pharmacological

Aliases: Nurtec ODT

Pharmacological Mechanism

Small-molecule CGRP receptor antagonist — competitive blockade at the CLR/RAMP1 receptor. Approved for both acute migraine treatment and migraine prevention (every-other-day dosing). No vasoconstriction → safe in CAD where triptans are contraindicated. CYP3A4 substrate.

Half-Life (t½)

PO: 11h

Dosing Guidelines

Target Organ Systems