Rifaximin

Category: pharmacological

Aliases: Xifaxan

Pharmacological Mechanism

Non-absorbed rifamycin — minimal systemic exposure (<1% bioavailability) means minimal CYP induction despite same PXR mechanism. Used for travelers diarrhea, hepatic encephalopathy (gut ammonia), and IBS-D (gut microbiome modulation).

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 400mg (Range: 200 - 550 mg)

Target Organ Systems

• digestive