Remdesivir

Category: pharmacological

Aliases: Veklury

Pharmacological Mechanism

Adenosine analog prodrug — intracellularly activated to remdesivir-TP, a delayed chain-terminator for SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). IV infusion for hospitalized COVID-19 + outpatient high-risk unable to take Paxlovid.

Half-Life (t½)

IV: 1h

Dosing Guidelines

• IV: Typical 200mg (Range: 100 - 200 mg)

Target Organ Systems

• immune-hematologic