Ranolazine

Category: pharmacological

Aliases: Ranexa

Pharmacological Mechanism

Late sodium current (INa-late) inhibitor in cardiomyocytes — reduces Ca²⁺ overload and improves diastolic function. Anti-anginal without significant heart-rate or BP effects. CYP3A4 + P-gp substrate; QT prolongation modest. Mild HbA1c reduction signal.

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 1000 mg (Range: 500–1000 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• Cardiac action potential (inhibitor) — late Na+ current (INaL)

Chemical Identifiers

• PubChem CID: 56959
• Formula: C24H33N3O4
• Molecular weight: 427.54 g/mol
• InChIKey: XKLMZUWKNUAPSZ-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O

References

• PMID 23355361