Quinine

Category: alkaloid

Pharmacological Mechanism

Cinchona-bark alkaloid; antimalarial via heme polymerization inhibition in Plasmodium digestive vacuole. Cardiac sodium-channel blockade explains the QT prolongation + nocturnal-leg-cramps off-label use.

Half-Life (t½)

PO: 11h

Dosing Guidelines

• PO: Typical 300 mg (Range: 200–600 mg)

Target Organ Systems

• immune-hematologic

Pathways It Modulates

• Anthelmintic + antiprotozoal targets (inhibitor) — heme polymerization

Chemical Identifiers

• PubChem CID: 3034034
• Formula: C20H24N2O2
• Molecular weight: 324.42 g/mol
• InChIKey: LOUPRKONTZGTKE-WZBLMQSHSA-N
• SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O

References

• PMID 12695533