Quinine

Category: alkaloid

Pharmacological Mechanism

Cinchona-bark alkaloid; antimalarial via heme polymerization inhibition in Plasmodium digestive vacuole. Cardiac sodium-channel blockade explains the QT prolongation + nocturnal-leg-cramps off-label use.

Half-Life (t½)

PO: 11h

Dosing Guidelines

• PO: Typical 300mg (Range: 200 - 600 mg)

Target Organ Systems

• immune-hematologic