Quinapril

Category: pharmacological

Aliases: Accupril

Pharmacological Mechanism

ACE inhibitor prodrug — same conversion-to-active-form mechanism as enalapril / ramipril. Once-daily dosing for hypertension + heart failure.

Half-Life (t½)

PO: 1.2h

Dosing Guidelines

• PO: Typical 20 mg (Range: 5–80 mg)

Target Organ Systems

• cardiovascular

Pathways It Modulates

• Bradykinin / kallikrein-kinin system (inhibitor) — ACE
• Renin-angiotensin-aldosterone axis (inhibitor) — ACE

Chemical Identifiers

• PubChem CID: 54892
• Formula: C25H30N2O5
• Molecular weight: 438.52 g/mol
• InChIKey: JSDRRTOADPPCHY-HSQYWUDLSA-N
• SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O

References

• PMID 18672641