Quetiapine

Category: pharmacological

Aliases: Seroquel

Pharmacological Mechanism

Multi-receptor antagonist with strong H1 + α1 activity → sedation. Brief D2 occupancy ('fast dissociation') → low EPS. Active metabolite norquetiapine adds NET inhibition + 5-HT1A partial agonism (rationale for MDD adjunct indication).

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 283mg (Range: 25 - 800 mg)

Target Organ Systems

• nervous