Quetiapine

Category: pharmacological

Aliases: Seroquel

Pharmacological Mechanism

Multi-receptor antagonist with strong H1 + α1 activity → sedation. Brief D2 occupancy ('fast dissociation') → low EPS. Active metabolite norquetiapine adds NET inhibition + 5-HT1A partial agonism (rationale for MDD adjunct indication).

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 283 mg (Range: 25–800 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Dopamine receptor signaling (inhibitor) — D2 antagonist (transient — high koff)
• Serotonin receptor pharmacology (inhibitor) — 5-HT2A antagonist (also H1, D2, M1)

Chemical Identifiers

• PubChem CID: 5002
• Formula: C21H25N3O2S
• Molecular weight: 383.51 g/mol
• InChIKey: URKOMYMAXPYINW-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42

References

• PMID 11510628
• PMID 38282365
• PMID 9430133
• PMID 12176106
• PMID 8935801