Pyrantel Pamoate

Category: pharmacological

Pharmacological Mechanism

Anthelmintic — depolarizing neuromuscular blocker for worms (nicotinic ACh agonist at parasite NMJ → spastic paralysis). OTC for pinworm; one-dose treatment with optional 2-week repeat. Minimally absorbed.

Half-Life (t½)

PO: 3h

Dosing Guidelines

• PO: Typical 11 mg (Range: 11–11 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Anthelmintic + antiprotozoal targets (activator) — parasite nAChR (depolarizing block)

Chemical Identifiers

• PubChem CID: 5281033
• Formula: C34H30N2O6S
• Molecular weight: 594.69 g/mol
• InChIKey: AQXXZDYPVDOQEE-MXDQRGINSA-N
• SMILES: CN1CCCN=C1/C=C/C2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O