Prucalopride

Category: pharmacological

Aliases: Motegrity

Pharmacological Mechanism

Selective serotonin 5-HT4 receptor agonist; prokinetic for chronic idiopathic constipation. Largely excreted unchanged in urine.

Half-Life (t½)

PO: 24h

Dosing Guidelines

• PO: Typical 2 mg (Range: 1–2 mg)

Target Organ Systems

• digestive

Notes

PK from FDA prescribing information (DailyMed setid af559917-802b-486c-9f7b-b770115acac8): absolute bioavailability >90% (F 0.9), steady-state Vd 567 L, terminal t½ ~1 day (24 h), Tmax 2–3 h, 60–65% excreted unchanged in urine. ka_hr 1.5 derived from Tmax ~2.5 h (ke from t½ 24 h).

Chemical Identifiers

• PubChem CID: 3052762
• Formula: C18H26ClN3O3
• Molecular weight: 367.9 g/mol
• InChIKey: ZPMNHBXQOOVQJL-UHFFFAOYSA-N
• SMILES: COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl

References

• PMID 10646498