Propranolol

Category: pharmacological

Aliases: Inderal, Inderal LA

Pharmacological Mechanism

Non-selective β₁/β₂ antagonist. High lipophilicity → excellent CNS penetration — the basis for migraine prophylaxis, essential tremor, and performance-anxiety uses. Black 1962 Nobel-Prize-level discovery. Infantile hemangioma indication added 2014.

Half-Life (t½)

PO: 4h, IV: 4h

Dosing Guidelines

• PO: Typical 33.3 mg (Range: 10–80 mg)
• IV: Typical 33.3 mg (Range: 10–80 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — β1 + β2 (non-selective)
• Wound healing cascade (inhibitor) — hemangioma (infantile) regression; off-label scar modulation

Chemical Identifiers

• PubChem CID: 4946
• Formula: C16H21NO2
• Molecular weight: 259.34 g/mol
• InChIKey: AQHHHDLHHXJYJD-UHFFFAOYSA-N
• SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O

References

• PMID 1982759
• PMID 15655528