Propofol

Category: pharmacological

Aliases: Diprivan

Pharmacological Mechanism

Lipid-soluble GABA-A positive allosteric modulator + glycine receptor potentiation. Workhorse IV induction + maintenance anesthetic; rapid onset (~30 sec) and short duration. Hypotension via vasodilation; "propofol infusion syndrome" (lactic acidosis, rhabdomyolysis) at prolonged high-dose ICU sedation.

Half-Life (t½)

IV: 4h

Dosing Guidelines

• IV: Typical 2mg (Range: 1 - 2.5 mg)

Target Organ Systems

• nervous
• cardiovascular