Promethazine

Category: pharmacological

Aliases: Phenergan

Pharmacological Mechanism

Phenothiazine first-generation H1 antihistamine + D2 antagonist + muscarinic antagonist. Sedating antiemetic + motion-sickness agent. IV extravasation causes severe tissue necrosis — black-box prefers deep IM or central line.

Half-Life (t½)

PO: 12h, IV: 12h

Dosing Guidelines

Target Organ Systems