Progesterone (micronized)

Category: hormone

Aliases: Prometrium, Utrogestan

Pharmacological Mechanism

Endogenous C21 progestogen. Activates progesterone receptor (PR-A, PR-B); GABA-A allosteric modulation by the metabolite allopregnanolone explains the sedative effect at oral micronized dosing. Used in menopausal HRT alongside estradiol to oppose endometrial proliferation.

Half-Life (t½)

PO: 18h

Dosing Guidelines

• PO: Typical 200mg (Range: 100 - 300 mg)

Target Organ Systems

• nervous
• endocrine
• reproductive