Prochlorperazine

Category: pharmacological

Aliases: Compazine

Pharmacological Mechanism

Phenothiazine D2 antagonist — antiemetic via chemoreceptor trigger zone D2 blockade. Anti-dopaminergic side effects (EPS, akathisia, dystonia) limit chronic use. Common for migraine + chemotherapy nausea + vertigo.

Half-Life (t½)

PO: 7h, IV: 7h

Dosing Guidelines

• PO: Typical 10mg (Range: 5 - 25 mg)

Target Organ Systems

• nervous
• immune-hematologic