Prochlorperazine

Category: pharmacological

Aliases: Compazine

Pharmacological Mechanism

Phenothiazine D2 antagonist — antiemetic via chemoreceptor trigger zone D2 blockade. Anti-dopaminergic side effects (EPS, akathisia, dystonia) limit chronic use. Common for migraine + chemotherapy nausea + vertigo.

Half-Life (t½)

PO: 7h, IV: 7h

Dosing Guidelines

• PO: Typical 10 mg (Range: 5–25 mg)

Target Organ Systems

• nervous
• immune-hematologic

Pathways It Modulates

• Dopamine receptor signaling (inhibitor) — D2 (phenothiazine)

Chemical Identifiers

• PubChem CID: 4917
• Formula: C20H24ClN3S
• Molecular weight: 373.95 g/mol
• InChIKey: WIKYUJGCLQQFNW-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl

References

• PMID 1768559