Pregabalin

Category: pharmacological

Aliases: Lyrica

Pharmacological Mechanism

α2δ Ca²⁺-channel ligand (same target as gabapentin) — better-defined PK with linear absorption (no saturable transporter). Approved for neuropathic pain, fibromyalgia, post-herpetic neuralgia, focal seizures. Schedule V (mild euphoria + abuse signal).

Half-Life (t½)

PO: 6.3h

Dosing Guidelines

• PO: Typical 150mg (Range: 25 - 600 mg)

Target Organ Systems

• musculoskeletal