Prazosin

Category: pharmacological

Aliases: Minipress

Pharmacological Mechanism

Short-acting selective α1-adrenergic blocker. BP lowering + BPH symptom relief. Off-label for PTSD-related nightmares + sleep disturbance (raised α1 tone in PTSD; prazosin softens hyperarousal during sleep).

Half-Life (t½)

PO: 3h

Dosing Guidelines

• PO: Typical 5mg (Range: 1 - 20 mg)

Target Organ Systems

• cardiovascular
• reproductive