Pitolisant

Category: pharmacological

Aliases: Wakix

Pharmacological Mechanism

Histamine H3 receptor antagonist / inverse agonist; raises central histamine to promote wakefulness (narcolepsy). CYP2D6 + CYP3A4 metabolism.

Half-Life (t½)

PO: 20h

Dosing Guidelines

• PO: Typical 17.8mg (Range: 17.8 - 35.6 mg)

Target Organ Systems

• nervous