Piperacillin / Tazobactam

Category: pharmacological

Aliases: Zosyn

Pharmacological Mechanism

Anti-pseudomonal penicillin (piperacillin) + β-lactamase inhibitor (tazobactam). Workhorse empiric IV for hospital-acquired pneumonia + intra-abdominal infections + febrile neutropenia. Synergy with aminoglycosides for severe Pseudomonas infections.

Half-Life (t½)

IV: 1h

Dosing Guidelines

• IV: Typical 3375mg (Range: 2250 - 4500 mg)

Target Organ Systems

• immune-hematologic