Piperacillin / Tazobactam

Category: pharmacological

Aliases: Zosyn

Pharmacological Mechanism

Anti-pseudomonal penicillin (piperacillin) + β-lactamase inhibitor (tazobactam). Workhorse empiric IV for hospital-acquired pneumonia + intra-abdominal infections + febrile neutropenia. Synergy with aminoglycosides for severe Pseudomonas infections.

Half-Life (t½)

IV: 1h

Dosing Guidelines

• IV: Typical 3375 mg (Range: 2250–4500 mg)

Target Organ Systems

• immune-hematologic

Pathways It Modulates

• Bacterial cell wall (inhibitor) — PBP + β-lactamase inhibitor

Chemical Identifiers

• PubChem CID: 23724843
• Formula: C33H38N9NaO12S2
• Molecular weight: 539.54 g/mol
• InChIKey: TUPFOYXHAYOHIB-WZGOVNIISA-M
• SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3.[Na+]