Pimecrolimus

Category: topical

Aliases: Elidel

Pharmacological Mechanism

Topical calcineurin inhibitor — same FKBP-12 / calcineurin pathway as tacrolimus, slightly less potent and lower systemic absorption. Approved for mild-to-moderate atopic dermatitis as a steroid alternative. Same FDA black-box (theoretical lymphoma).

Half-Life (t½)

TD: 12h

Dosing Guidelines

• TD: Typical 1 mg (Range: 1–1 mg)

Target Organ Systems

• integumentary
• immune-hematologic

Pathways It Modulates

• Calcineurin / NFAT T-cell activation (inhibitor) — calcineurin (topical, FKBP-binding)
• Topical anti-inflammatory skin Rx (inhibitor) — calcineurin — TCI, weaker than tacrolimus-topical

Chemical Identifiers

• PubChem CID: 6509979
• Formula: C43H68ClNO11
• Molecular weight: 810.46 g/mol
• InChIKey: KASDHRXLYQOAKZ-XDSKOBMDSA-N
• SMILES: CC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@@H]([C@@H](C4)OC)Cl)/C)O)C)OC)OC)C)\C