Perampanel

Category: pharmacological

Aliases: Fycompa

Pharmacological Mechanism

Selective non-competitive AMPA glutamate receptor antagonist — first-in-class. Adjunct for partial-onset + primary generalized tonic-clonic seizures. Black-box for psychiatric / behavioral adverse effects (aggression, suicidality).

Half-Life (t½)

PO: 105h

Dosing Guidelines

• PO: Typical 8 mg (Range: 2–12 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Glutamate receptor pharmacology (inhibitor) — AMPA receptor (selective non-competitive)
• Metabotropic glutamate receptors (inhibitor) — AMPA antagonist (downstream of mGluR)

Chemical Identifiers

• PubChem CID: 9924495
• Formula: C23H15N3O
• Molecular weight: 349.39 g/mol
• InChIKey: PRMWGUBFXWROHD-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4

References

• PMID 28535410