Perampanel

Category: pharmacological

Aliases: Fycompa

Pharmacological Mechanism

Selective non-competitive AMPA glutamate receptor antagonist — first-in-class. Adjunct for partial-onset + primary generalized tonic-clonic seizures. Black-box for psychiatric / behavioral adverse effects (aggression, suicidality).

Half-Life (t½)

PO: 105h

Dosing Guidelines

• PO: Typical 8mg (Range: 2 - 12 mg)

Target Organ Systems

• nervous