Penicillin V

Category: pharmacological

Aliases: Phenoxymethylpenicillin

Pharmacological Mechanism

Acid-stable orally-absorbed penicillin — inhibits bacterial transpeptidase (PBPs) crosslinking peptidoglycan. Streptococcal coverage for strep pharyngitis, secondary prophylaxis of rheumatic fever, dental prophylaxis (where indicated). Renal-cleared.

Half-Life (t½)

PO: 1h, IV: 1h

Dosing Guidelines

• PO: Typical 500 mg (Range: 250–500 mg)

Target Organ Systems

• renal

Pathways It Modulates

• Bacterial cell wall (inhibitor) — PBP (β-lactam)

Chemical Identifiers

• PubChem CID: 6869
• Formula: C16H18N2O5S
• Molecular weight: 350.39 g/mol
• InChIKey: BPLBGHOLXOTWMN-MBNYWOFBSA-N
• SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)COC3=CC=CC=C3)C(=O)O)C

References

• PMID 2515160