Palonosetron

Category: pharmacological

Aliases: Aloxi

Pharmacological Mechanism

Long-acting 5-HT3 antagonist — same target as ondansetron with 30× higher receptor affinity + 40h half-life. Single-dose efficacy through 5-day chemo-induced nausea window.

Half-Life (t½)

IV: 40h

Dosing Guidelines

• IV: Typical 0.25mg (Range: 0.25 - 0.5 mg)

Target Organ Systems

• digestive
• nervous