Palonosetron

Category: pharmacological

Aliases: Aloxi

Pharmacological Mechanism

Long-acting 5-HT3 antagonist — same target as ondansetron with 30× higher receptor affinity + 40h half-life. Single-dose efficacy through 5-day chemo-induced nausea window.

Half-Life (t½)

IV: 40h

Dosing Guidelines

• IV: Typical 0.25 mg (Range: 0.25–0.5 mg)

Target Organ Systems

• digestive
• nervous

Pathways It Modulates

• GI motility + secretion (inhibitor) — 5-HT3 (long-acting)

Chemical Identifiers

• PubChem CID: 6337614
• Formula: C19H24N2O
• Molecular weight: 296.41 g/mol
• InChIKey: CPZBLNMUGSZIPR-NVXWUHKLSA-N
• SMILES: C1C[C@@H]2CN(C(=O)C3=CC=CC(=C23)C1)[C@@H]4CN5CCC4CC5

References

• PMID 15102873
• PMID 23581504