Vitamin B6 (P5P)

Category: vitamin

Aliases: pyridoxal-5-phosphate, b6

Pharmacological Mechanism

Cofactor for >100 enzymes including neurotransmitter synthesis.

Half-Life (t½)

PO: 25h

Dosing Guidelines

• PO: Typical 10 (Range: 5–50)

Target Organ Systems

• nervous

Interactions

• Pyridoxine (B6) (synergistic): Same family — P5P is the activated form. Pick one.

Notes

Chronic >100mg/day risks peripheral neuropathy.

Pathways It Modulates

• Transsulfuration → cysteine → glutathione (cofactor) — CBS + CSE B6-dependent cofactor
• Vitamin B6 metabolism (cofactor) — pyridoxal-5-phosphate (active B6 form)

Chemical Identifiers

• PubChem CID: 1051
• Formula: C8H10NO6P
• Molecular weight: 247.14 g/mol
• InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N
• SMILES: CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O

References

• PMID 18078852
• PMID 21079545