Oxymorphone

Category: alkaloid

Aliases: Opana

Pharmacological Mechanism

Semi-synthetic μ-opioid agonist; ~10× morphine potency PO, ~2× IV. Active metabolite of oxycodone via CYP2D6. Reformulated extended-release version (2017) reduces IV abuse but didn't prevent pivot to other agents.

Half-Life (t½)

PO: 9h, IV: 9h

Dosing Guidelines

Target Organ Systems