Oxymetazoline

Category: topical

Aliases: Afrin

Pharmacological Mechanism

Imidazoline α1A + partial α2 adrenergic agonist — topical vasoconstrictor for nasal congestion. Rebound congestion (rhinitis medicamentosa) develops with use >3 days. Topical formulation also approved for adult facial rosacea erythema (Rhofade).

Half-Life (t½)

IN: 6h

Dosing Guidelines

• IN: Typical 0.05mg (Range: 0.05 - 0.05 mg)

Target Organ Systems

• cardiovascular
• integumentary