Oxybutynin

Category: pharmacological

Aliases: Ditropan

Pharmacological Mechanism

Anticholinergic + direct antispasmodic — competitive M3 muscarinic antagonist on detrusor + spasmolytic on bladder smooth muscle. First-line for overactive bladder. Anticholinergic burden — Beers-list problematic in elderly (cognitive impairment + dementia signal at chronic exposure).

Half-Life (t½)

PO: 2h, TD: 7.5h

Dosing Guidelines

• PO: Typical 10 mg (Range: 5–30 mg)

Target Organ Systems

• renal

Pathways It Modulates

• Acetylcholine synthesis + degradation (inhibitor) — muscarinic M1/M3 (urinary)
• Muscarinic ACh receptor subtypes (inhibitor) — M3 (urinary; CNS side effects in elderly — high anticholinergic burden)

Chemical Identifiers

• PubChem CID: 4634
• Formula: C22H31NO3
• Molecular weight: 357.49 g/mol
• InChIKey: XIQVNETUBQGFHX-UHFFFAOYSA-N
• SMILES: CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O

References

• PMID 10073329
• PMID 22243489