Oseltamivir

Category: pharmacological

Aliases: Tamiflu

Pharmacological Mechanism

Influenza neuraminidase inhibitor prodrug — hydrolyzed to active oseltamivir carboxylate by hepatic carboxylesterase. Blocks release of newly assembled virions from infected respiratory epithelial cells. Modest symptom-duration reduction (~1 day) when started <48h from symptom onset.

Half-Life (t½)

PO: 7h

Dosing Guidelines

Target Organ Systems