Orphenadrine

Category: pharmacological

Aliases: Norflex

Pharmacological Mechanism

Anticholinergic + NMDA antagonist + weak NET inhibitor — centrally-acting muscle relaxant for acute musculoskeletal pain. Anticholinergic burden similar to cyclobenzaprine; Beers-list problematic.

Half-Life (t½)

PO: 16.5h, IV: 16.5h

Dosing Guidelines

• PO: Typical 100mg (Range: 100 - 200 mg)

Target Organ Systems

• nervous
• musculoskeletal