Orlistat

Category: pharmacological

Aliases: Xenical, Alli

Pharmacological Mechanism

Irreversibly inhibits pancreatic + gastric lipases via covalent serine modification → blocks hydrolysis of dietary triglycerides → ~30% of ingested fat passes unabsorbed. Modest weight loss 3–6% at 1 year. Largely unabsorbed systemically — acts locally in gut lumen.

Half-Life (t½)

PO: 1.5h

Dosing Guidelines

Target Organ Systems

Interactions