Ondansetron

Category: pharmacological

Aliases: Zofran

Pharmacological Mechanism

5-HT3 receptor antagonist — blocks vagal afferent emetic signaling from the GI tract + chemoreceptor trigger zone. First-line for chemotherapy-induced + post-operative nausea. CYP3A4/2D6 substrate. QT prolongation at IV doses ≥ 16 mg.

Half-Life (t½)

PO: 3.5h, IV: 3.5h

Dosing Guidelines

• PO: Typical 8 mg (Range: 4–24 mg)

Target Organ Systems

• digestive
• immune-hematologic

Pathways It Modulates

• Serotonin receptor pharmacology (inhibitor) — 5-HT3

Chemical Identifiers

• PubChem CID: 4595
• Formula: C18H19N3O
• Molecular weight: 293.36 g/mol
• InChIKey: FELGMEQIXOGIFQ-UHFFFAOYSA-N
• SMILES: CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C

References

• PMID 23581504