Oleocanthal

Category: polyphenol

Pharmacological Mechanism

Phenolic dialdehyde unique to extra-virgin olive oil. Ibuprofen-like COX-1 / COX-2 inhibition — gives EVOO its anti-inflammatory peppery throat catch. Implicated in Mediterranean diet cardiovascular benefit.

Half-Life (t½)

PO: 1h

Dosing Guidelines

• PO: Typical 4 mg (Range: 1–9 mg)

Target Organ Systems

• cardiovascular
• immune-hematologic

Pathways It Modulates

• Nrf2 / Keap1 antioxidant response (activator) — COX inhibitor (ibuprofen-like) + Nrf2

Chemical Identifiers

• PubChem CID: 11652416
• Formula: C17H20O5
• Molecular weight: 304.34 g/mol
• InChIKey: VPOVFCBNUOUZGG-VAKDEWRISA-N
• SMILES: C/C=C(/C=O)\[C@@H](CC=O)CC(=O)OCCC1=CC=C(C=C1)O