NSI-189

Category: nootropic

Pharmacological Mechanism

Hippocampal neurogenesis stimulator — exact mechanism partially defined; raises BDNF + ERK1/2 + dentate gyrus neurogenesis in animal studies. Failed Phase 2 for major depressive disorder in 2017; biohacker interest persists.

Half-Life (t½)

PO: 17h

Dosing Guidelines

• PO: Typical 40 mg (Range: 40–80 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• AMPA + kainate glutamate receptor modulation (activator) — BDNF/neurogenesis (research)

Chemical Identifiers

• PubChem CID: 50922681
• Formula: C22H30N4O
• Molecular weight: 366.5 g/mol
• InChIKey: DYTOQURYRYYNOR-UHFFFAOYSA-N
• SMILES: CC(C)CCNC1=C(C=CC=N1)C(=O)N2CCN(CC2)CC3=CC=CC=C3