Nilotinib

Category: pharmacological

Aliases: Tasigna

Pharmacological Mechanism

Second-generation BCR-ABL tyrosine kinase inhibitor; ~30× imatinib potency. Used in imatinib-resistant or front-line CML. Strong CYP3A4 inhibitor; QT prolongation black-box. Food triples Cmax — must be taken fasted.

Half-Life (t½)

PO: 17h

Dosing Guidelines

• PO: Typical 600mg (Range: 300 - 800 mg)

Target Organ Systems

• digestive