Nateglinide

Category: pharmacological

Aliases: Starlix

Pharmacological Mechanism

Meglitinide — same K-ATP channel closure mechanism as repaglinide, faster onset. Pre-prandial dosing for post-prandial glucose. CYP2C9 + CYP3A4 substrate.

Half-Life (t½)

PO: 1.5h

Dosing Guidelines

• PO: Typical 120 mg (Range: 60–360 mg)

Target Organ Systems

• digestive

Pathways It Modulates

• Insulin signaling + glucose homeostasis (activator) — KATP channel block (SUR1)
• PPAR α / γ / δ nuclear receptor signaling (activator) — PPARγ (weak)

Chemical Identifiers

• PubChem CID: 5311309
• Formula: C19H27NO3
• Molecular weight: 317.43 g/mol
• InChIKey: OELFLUMRDSZNSF-OFLPRAFFSA-N
• SMILES: CC(C)C1CCC(CC1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)O

References

• PMID 15005635